MYD88L265P Detection in IgM Monoclonal Gammopathies: Methodological Considerations for Routine Implementation
نویسندگان
چکیده
منابع مشابه
Screening panels for detection of monoclonal gammopathies.
BACKGROUND The repertoire of serologic tests for identifying a monoclonal gammopathy includes serum and urine protein electrophoresis (PEL), serum and urine immunofixation electrophoresis (IFE), and quantitative serum free light chain (FLC). Although there are several reports on the relative diagnostic contribution of these assays, none has looked at the tests singly and in combination for the ...
متن کاملMonoclonal gammopathies
Clinical background The finding of a monoclonal immunoglobulin in the serum defines the so-called monoclonal gammopathy. Monoclonal components are homogeneus immunoglobulins whole (intact) or fragmented, produced by a single expanded plasma cell clone. MCs present unique physicochemical homogeneity, which is reflected in their immunological homogeinity. Immunological homogeinity by electrophore...
متن کاملScreening panels for detection of monoclonal gammopathies: confidence intervals.
ported criteria of S/LC -cTnI 6.7 or S/LC -cTnT 5.3 (1, 2 ). Taken together, 55 (15.9%) of the 345 samples were positive for autoantibodies to cardiac troponin I or T isoforms. In these positive samples, 10.9% (6 of 55) were positive for both autoantibodies. The odds of being positive for both autoantibodies increased in the presence of either species; in samples positive for autoantibodies to ...
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In this issue of Clinical Chemistry, Piehler et al. (1 ) present data on the use of serum protein electrophoresis (SPE), clinical history, and selective use of serum immunoglobulin free light chain (FLC) assay as a diagnostic screening algorithm for multiple myeloma (MM) in a general hospital population and conclude that this algorithm allows for efficient diagnosis or exclusion of multiple mye...
متن کاملAL-amyloidosis in monoclonal gammopathies.
Sixty-two patients affected by MGUS underwent fat tissue aspirate examination for diagnosis of AL amyloidosis. Nine out of the 62 were found to be Congo red positive. MGUS had already been diagnosed for quite a long time in about 60% of these patients, while this prevalence decreased to 24% among the Congo red negative patients. The follow-up of the positive patients is reported.
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ژورنال
عنوان ژورنال: Diagnostics
سال: 2021
ISSN: 2075-4418
DOI: 10.3390/diagnostics11050779